I used this product this past summer, as I've been diagnosed with SIBO and always looking for the miracle product to rid myself of it. I read where if you have SIBO, you most likely have/will have leaky gut. I asked my ND if I most likely had leaky gut now that I have SIBO. He said NO. (He seems to not like the fact that I read health articles and research natural treatments, both on the internet and in publications). So I finished my bottle of Permeable Gut and canceled the next order. However, it was sent anyway. So, I started taking that bottle to get rid of it. I also started finishing off some Saccharomyces Boulardii that I found in the fridge. I continued taking a professional brand of garlic capsules, neem and oil of oregano that I had been taking for some time without experiencing much in the way of positive results. Well, after a couple weeks of continuing using the PG and the SB, I noticed I was feeling much better and my bloat and gas had greatly diminished. I had a flat stomach again! I thought it was the garlic, neem and oregano finally kicking in, since I had been told I didn't have leaky gut. A couple weeks later I ran out of the Permeable Gut and the Saccharomyces Boulardii. Soon after, my symptoms all reappeared-the bloating, the gas, the general puffiness. I realized that it had to be the Permeable Gut and possibly the probiotic strain. So, I am ordering more PG and am going to faithfully take it to see if I get the same great results. Perhaps I DO have leaky gut, Dr. Ego. I will be telling him about the PG it I do see improvement. I will also update here.